Predicts which sequences may bind
- Learns mainly from binding data
- Limited insight into other functional characteristics
BindingSequenceStructure
AI aptamer design for therapeutics
Designing aptamers for the full therapeutic challenge.
PentaBind combines proprietary AI with experimental validation to create target-specific, drug-like aptamers engineered beyond binding.
Engineered affinityTarget engagement by design
Built-in selectivityDiscrimination where it matters
Tunable stabilityOptimised for biological conditions
Functional performanceFrom localisation to modulation
The platform
An AI platform that goes beyond binding
Our models learn from sequence, structure and measured experimental outcomes. Every design cycle expands the proprietary dataset and improves the next.
01
Predict
Proprietary models design candidates against the performance profile the therapeutic needs.
02
Validate
Wet-lab testing measures affinity, selectivity, stability, localisation and functional response.
03
Optimise
Results feed back into the platform to focus designs on target-specific, drug-like performance.
A closed AI and wet-lab loop built on proprietary methods and data
Our advantage
AI matters.
The training data matters more.
PentaBind learns from multi-characteristic experimental data, linking sequence and structure to the measured outcomes that determine whether an aptamer can become a therapeutic asset.
Designs for the full performance needed in use
- Learns from measured, multi-characteristic data
- Links sequence, structure and experimental outcomes
AffinitySelectivityStabilityLocalisationFunction
PentaBind designs multi-characteristic aptamers, not just binders.
Aptamers: Engineered for Therapeutic Performance
Compact targeting ligands, built for demanding biology
01
Affinity
Strong target engagement at therapeutically relevant concentrations.
02
Selectivity
Discrimination across closely related proteins and disease-specific forms.
03
Stability
Sequence and chemistry optimisation for performance in biological conditions.
04
Delivery and function
Internalisation, localisation and functional modulation designed into the asset brief.
Built in the lab
Real experiments strengthen every design cycle
Our in-house team generates the sequence–structure–function data that trains the platform. The result is a compounding advantage rooted in experimental evidence.
Meet PentaBindPartner with PentaBind
Create a high-value aptamer asset
We work with therapeutics partners to design the performance their application needs.
Create a new aptamer asset
Start from an important product need and define a target-specific performance profile.
Improve an aptamer
Optimise an existing sequence to increase performance across the characteristics that matter.
Find stronger opportunities
Use discovery data to identify higher-value aptamer asset opportunities.
Partner-ready aptamer asset
Designed for the performance your therapeutic needs
Discuss a programme